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KMID : 0980720130320010051
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Keimyung Medical Journal
2013 Volume.32 No. 1 p.51 ~ p.60
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A Comparison of Hematologic Indices between Aspirin/Clopidogrel Responders and Non-responders in Patients with Cardiovascular Disorders
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Lee Jae-Hee
Park Sung-Gyun
Kim Kyoung-Bo
Lee Won-Mok
Ha Jung-Sook
Ryoo Nam-Hee
Jeon Dong-Suk
Kim Jae-Ryong
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Abstract
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It is important to detect aspirin and clopidogrel resistance to improve clinical outcomes in atherothrombotic disorders. This study aimed to investigate any hematologic parameter to predict anti-platelet agents resistance. 543 patients who had been treated with dual therapy for 2 weeks were divided into 4 groups using the drug resistance test, VerifyNow (Accumetrics, USA): nonresponders to both aspirin and clopidogrel (group A), non-responders to only aspirin (group B), non-responders to only clopidogrel (group C), and responders to both aspirin and clopidogrel (group D). Hematologic findings were collected before and after dual therapy. The platelet count in group B and the WBC count in group C were lower compared to group D before therapy. After medication, the platelet counts in groups A and C were lower than that of group D. However, all of these changes were developed within normal limits. When analyzing hematologic changes in each group before and after medication, the platelet count in group A was increased although other groups showed decreasing pattern of platelets. In conclusion, no profound hematologic index was found to suggest anti-platelet drug resistance, but the evaluation of hematologic changes before and after anti-platelet medication may be potential predictive parameters.
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KEYWORD
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Aspirin, Clopidogrel, Hematologic index, Resistance
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